Which population has shown significant benefits from beta-hydroxy-beta-methylbutyrate (HMB) supplementation?

Beta-hydroxy-beta-methylbutyrate (HMB) supplementation is particularly beneficial for resistance-trained athletes due to its role in promoting muscle protein synthesis and reducing muscle breakdown. HMB is a metabolite of the amino acid leucine, which is known for its anabolic properties. For resistance-trained athletes, HMB can help enhance strength gains, improve recovery after intense training, and support muscle mass preservation during periods of caloric deficit or heavy training.

This population experiences greater muscle stress due to weightlifting and other resistance activities, resulting in the need for effective recovery strategies. HMB assists in mitigating muscle damage and soreness, thus allowing athletes to train more efficiently and consistently.

While other populations such as recreational gym-goers or active individuals over 50 may also derive some benefits from HMB, the evidence is particularly strong for those engaged in structured resistance training, where the effects on muscle growth and recovery are more pronounced. Furthermore, endurance athletes typically do not benefit as much from HMB, as their training focuses more on cardiovascular fitness rather than resistance and muscle building.