Which B-vitamin plays a critical role in the synthesis of coenzyme A?

Pantothenic acid, commonly known as vitamin B5, is essential for the synthesis of coenzyme A, a crucial cofactor in various metabolic reactions, including the metabolism of fats, carbohydrates, and proteins. Coenzyme A is involved in the Krebs cycle and is necessary for the synthesis and oxidation of fatty acids. Pantothenic acid is a component of coenzyme A, meaning that an adequate intake of this vitamin directly supports its formation and function.

While folate, biotin, and vitamin B6 have important roles in various biological processes, they do not contribute to the synthesis of coenzyme A. Folate is primarily involved in DNA synthesis and repair, biotin is important for carboxylation reactions, and vitamin B6 participates in amino acid metabolism and neurotransmitter synthesis. Each of these vitamins serves its unique functions, but pantothenic acid alone is directly responsible for the formation of coenzyme A.