Where is IGF-1 primarily produced in the body?

Insulin-like Growth Factor 1 (IGF-1) is primarily produced in the liver as a response to stimulation by growth hormone (GH). This production is essential for various physiological processes, including growth, development, and metabolic regulation. The liver synthesizes IGF-1 and releases it into the bloodstream, where it has systemic effects on tissues throughout the body, such as promoting cellular growth and proliferation.

While other tissues such as muscles, brain, and fat tissues can produce IGF-1 to some degree, the liver serves as the main source for circulating IGF-1, which plays a critical role in the body's growth and metabolic processes. This makes the liver a crucial organ in regulating the levels and activity of IGF-1.