What is the primary function of the Cori cycle?

The primary function of the Cori cycle is to regenerate glucose from lactate. This process is crucial during periods of intense exercise when oxygen levels are low, leading to anaerobic metabolism. As muscles work hard, they produce lactic acid from pyruvate, which is then converted back into lactate. The lactate is transported to the liver, where it can be converted back into glucose through gluconeogenesis. This newly created glucose can then be released back into the bloodstream and used by the muscles for energy, thus providing a way to maintain blood glucose levels and supply energy to working muscles under anaerobic conditions.

This mechanism also helps in preventing the buildup of lactate in the muscles, which can contribute to fatigue. Hence, the regeneration of glucose from lactate is a vital part of the body's metabolic strategy during high-intensity exercise.