What effect does supplementation with alpha-hydroxy-isocaproic acid (HICA) have on muscle mass?

Supplementation with alpha-hydroxy-isocaproic acid (HICA) has been studied for its potential effects on muscle mass, particularly in the context of resistance training and recovery. The correct assertion that HICA leads to small increases in muscle mass is based on its role as a metabolite of the branched-chain amino acid leucine, which is known to have anabolic properties.

HICA is thought to promote muscle protein synthesis and inhibit muscle protein breakdown, contributing to a favorable environment for muscle growth. Research indicates that HICA supplementation may help support recovery following intense exercise, leading to better retention of muscle mass and potentially supporting gains in strength as a result of improved recovery.

In summary, the evidence surrounding HICA suggests that it promotes a slight enhancement in muscle mass, particularly beneficial for individuals involved in resistance training or intense physical activities. This aligns with findings that point toward the compound aiding in the preservation of muscle during periods of physical stress or calorie restriction.