What effect does niacin supplementation have on free fatty acids (FFA)?

Niacin supplementation is known to reduce free fatty acid (FFA) levels in the bloodstream. This is primarily due to its action on adipose tissue, where niacin inhibits lipolysis — the breakdown of fat stores into FFAs. When lipolysis is reduced, there is a decrease in circulating FFAs, leading to lower levels in the bloodstream.

In addition to its effect on FFAs, niacin also improves lipid profiles by increasing HDL cholesterol levels and affecting triglycerides, but its most significant action in this context is its ability to lower FFAs. This reduction can have various implications for metabolism and energy production, particularly during exercise or in individuals with metabolic conditions. Understanding this mechanism is critical for athletes or those looking to manage their metabolic health through dietary supplements.